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With aging, muscle stem cell function gradually declines, showing reduced proliferation and fusion, leading to impaired regeneration-one of the key mechanisms underlying sarcopenia.In vitro experiments confirm that 5-amino-1mq significantly enhances the proliferation and fusion of muscle stem cells from aged mice
However, we would suggest that future clinical trials should aim to assess the cost-effectiveness of screening older people with obesity who are undergoing weight management interventions for evidence of sarcopenia, through clinical evaluation including hand grip tests, which are accurate biomarkers for overall strength and function, bone mineral density and consequent fracture risk, and cardiometabolic disease [123]
Journal of Physiology, 110(4), 1223-1229
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